Abstract and Figures. Selenium is an essential micronutrient in diverse organisms. Two routes are known for its insertion into proteins and nucleic acids, via selenocysteine and 2-selenouridine ...

Abstract Glutathione peroxidase is an important enzyme in cellular antioxidant defense systems, detoxifying peroxides and hydroperoxides. ... (34.0 +/- 2.6), and medium without selenium and containing cycloheximide (37.6 +/- 1.3). These data suggest that protein synthesis is needed for selenium repletion to exert control on glutathione ...

Abstract A fast protein liquid chromatographic method for purification of selenium-containing phycocyanin (Se-PC) from selenium-enriched Spirulina platensis was described in this study. The purification procedures involved fractionation by ammonium sulfate precipitation, DEAE-Sepharose ion-exchange chromatography and Sephacry S-300 size ...

Selenium-containing nanomaterial has been realized as a promising biomaterial during the last decade. Li and Xu discuss the development of selenium-containing nanomaterials as drug delivery carriers and anticancer drugs for cancer treatment. The nanomaterials with promising in vitro and in vivo performances are expected for clinical cancer therapies.

Abstract. Selenium-containing compounds have emerged as a potentially promising treatment for viral infections and tumor development and dissemination. Selenium per se is often considered as a toxic element with little or no beneficial effects, but considerable advances have been made in the understanding of the complex biology, chemistry and ...

Abstract. Selenium (Se) is an essential micronutrient of organism and has important function. It participates in the functions of selenoprotein in several manners. In recent years, Se has attracted much attention because of its therapeutic potential against several diseases. Many natural and synthetic organic Se-containing compounds were ...

Objective In the present study we describe the synthesis and antioxidant activity in vitro of new 7-chloroN (arylselanyl)quinolin-4-amines 5 by the reaction of 4,7-dichloroquinoline 4 with ...

Until recently, few researchers have looked at selenium-containing polymers as novel biomaterials. In this Account, we summarize our recent research on selenium …

Abstract. Mild and 'green' ultrasound-assisted reaction of chitin with 3- (chloromethyl) [1,2,4]selenadiazolo [4,5- a ]pyridin-4-ium bromide in water affords novel selenium-containing cationic chitin derivatives. The thus obtained chitin derivatives are water soluble and are characterized by high in vitro antifungal activity comparable with ...

1 Introduction. Organoselenium compounds include a wide variety of molecules with broad application in organic synthesis, materials science, medicinal chemistry, and biology. 1-3 A growing repertoire of selenium-containing small molecules have been employed as catalysts, ligands, and unconventional synthetic intermediates …

These unique properties of selenium-containing peptides have found numerous applications in the field of chemical biology. For instance, selenium-containing peptides have been used in native chemical ligation (NCL). In addition, the reactivity of Sec can be harnessed to create cyclic and stapled peptides. ... Abstract: In recent years ...

Abstract Background: Inflammatory bowel disease (IBD) is characterized by chronic relapsing inflammation of the gastrointestinal tract. Oxidative stress plays a pivotal role in the pathogenesis of IBD. ... Selenium-containing amino acids reportedly have anti-oxidative and anti-inflammatory properties, but it remains unknown if selenium ...

Role of selenium-containing proteins in T-cell and macrophage function Proc Nutr Soc. 2010 Aug;69(3):300-10. doi: 10.1017/S002966511000176X. ... Abstract Selenium (Se) has been known for many years to have played a role in boosting the immune function, but the manner in which this element acts at the molecular level in host defence and ...

Abstract Selenium (Se)-containing compounds have emerged as potential therapeutic agents for the treatment of a range of diseases. Through tremendous effort, …

Abstract As an essential trace element, selenium (Se) plays a tremendous role in the functioning of the human organism being used for the biosynthesis of selenoproteins (proteins containing one or several selenocysteine residues). The functions of human selenoproteins in vivo are extremely diverse. Many selenoproteins have an …

Selenium (Se)-containing compounds have emerged as potential therapeutic agents for the treatment of a range of diseases. Through tremendous effort, considerable knowledge has been acquired to understand the complex chemical properties and biological activities of selenium, especially after its incorporation into bioactive molecules. From …

Abstract. Due to their unique properties, selenium-containing polymers have become one of the research focuses of polymer materials in recent years. First, selenium can transform among various states of …

The aim of the present study was to obtain a selenium-containing polysaccharide, ... Show abstract. Recently, lentinan (LNT) has been utilized for its diversified potential in research with an extended role from nutritional or medicinal applications to a novel biomaterial. LNT is a biocompatible, multifunctional …

Abstract Selenium (Se) has been known for its beneficial biological roles for several years, but interest in this trace element has seen a significant increase in the past couple of decades. ... This review aims to showcase the applications of selenium-containing peptides that have been reported in recent decades. This article summarizes their ...

Selenium-containing compounds have emerged as a potentially promising treatment for viral infections and tumor development and dissemination.

ChemInform Abstract: An Efficient Synthesis of 2-Aminobenzoxazoles and 2-Aminobenzothiazoles from 2-Aminophenols or 2-Aminothiophenols and Isoselenocyanates. Selenium-containing heterocycles: Part ...

Two novel selenium polysaccharide fractions (SeTPS-1 and SeTPS-2) were isolated purified, characterized from Se-enriched tea. The results showed that the molecular weights and Se content of SeTPS-1 and SeTPS-2 were 1.7 × 10 4 Da, 1.3 × 10 4 Da, and 23.50 μg/g and 13.47 μg/g, respectively. SeTPS-1 and SeTPS-2 had absorption spectra …

The role of selenium (Se) and Ulva fasciata as potent cancer chemopreventive and chemotherapeutic agents has been supported by epidemiological, preclinical, and clinical studies. In this study, Se-containing polysaccharide-protein complex (Se-PPC), a novel organoselenium compound, a Se-containing polysaccharide-protein …

Abstract Selenium is an essential micronutrient with important functions in human health and relevance to several pathophysiological conditions. The biological effects of selenium are largely mediated by selenium-containing proteins (selenoproteins) that are present in all three domains of life. ...

In this Account, we summarize our recent research on selenium-containing polymers and show their potential application as mild-responsive drug delivery vehicles …

The review presents the latest data on the role of selenium-containing agents in the regulation of diseases of the immune system. We mainly considered the contributions of selenium-containing compounds such as sodium selenite, methylseleninic acid, selenomethionine, and methylselenocysteine, as well as selenoproteins and …

Abstract Selenium-containing amino acids have attracted increasing interest from view points of the importance as active centers of several selenoenzymes, the biological synthesis, the metabolism, and the use for structure determination of proteins. In this article, our recent progresses in the transformation from sulfur-containing amino acids ...

Abstract NK cell-based immunotherapy and pemetrexed (Pem)-based chemotherapy have broad application prospects in cancer treatment. ... Herein, we construct a series of selenium-containing nanoparticles to synergistically enhance Pem-based chemotherapy and NK cell-based immunotherapy. The nanoparticles could deliver Pem to tumor sites …

Some selenium-containing proteins and peptides prepared from plant extracts are beneficial for protecting the body's health and resisting external disturbances. In the present study, selenium-containing peptide species were prepared from selenium-enriched Pleurotus eryngii protein hydrolysates and to evaluate the benefits of selenium …

Abstract. Context. Selenium-containing protein from selenium-enriched Spirulina platensis (Se-SP) (syn. Arthrospira platensis [Microcoleaceae]) showed novel antioxidant activity. However, the protective effect of Se-SP against oxygen glucose deprivation (OGD)-induced neural apoptosis has not been reported yet. ... Research …