The generator that produces the isotope is produced on a per-need basis, and is replaced every 28, 35, 42, or 49 days, in compliance with the regulations regarding radioactive material dictated by the United States …

• Breakthrough amounts of Sr-85 and Sr-82, considered to be impurities, should have been limited to 15 µCi (Sr-85) and 1.5 µCi (Sr-82) for 75 mCi of Rb activity 7 75 mCi of Rb activity. • One index patient had amounts 7 and 125 times these limits, 105 µCi of Sr-85 and 188 µCi of Sr-82, but these estimates had a high degree of

Ruby-Fill Generator; Descriptions. Rubidium Rb 82 injection is used in adults to help diagnose heart disease. It is used in a procedure called a positron emission tomography (PET) scan to help your doctor see an image of your heart. This medicine shows how much blood is getting to your heart muscle when you are resting or …

The two systems used in these imaging scans, CardioGen-82 and Ruby-Fill (rubidium Rb 82 generator) require additive- free 0.9% Sodium Chloride Injection USP to safely elute the system.

Excess radiation exposure occurs when the levels of Sr 82 or Sr 85 in the rubidium Rb 82 chloride injection exceed limits. Record eluate volume, including waste and test volumes. Strictly adhere to the generator eluate testing protocol. Stop using the generator if it reaches any of its Expiration Limits .

The RUBY-FILL® Rubidium 82 Generator contains an accelerator produced Strontium-82, which decays to Rubidium-82. When the generator is eluted with saline it produces a sterile, non-pyrogenic solution of Rb-82 Chloride. Due to the short half-life (75 s) of Rb-82, the use of an elution system is required for delivery of the Rb-82 Chloride into a ...

levels of Sr 82 or Sr 85 in the rubidium Rb 82 chloride injection exceed specified limits. • To monitor for Strontium contaminates generator eluate tests are perform at specific frequencies. • Unintended radiation exposure occurs when the Sr-82 and Sr-85 levels in rubidium Rb 82 chloride

Rubidium Rb 82 chloride injection is a radioactive diagnostic agent indicated for Positron Emission Tomography (PET) imaging of the …

The invention relates to a strontium-82/rubidium- 82 generator, comprising a column filled with a cationic ex-changer loaded with strontium-82, and having an inlet and an outlet, and a liquid medium, wherein parts of the column, inlet and outlet coming into contact with the liquid medium are iron-free, preferably metal-free, to a method for producing rubidium …

Directions for Eluting Rubidium Rb 82 Chloride Injection Use only additive-free 0.9 % Sodium Chloride Injection USP to elute the generator [see Boxed Warning, Contraindications, and Warnings and Precautions ]. Prepare the 0.9 % Sodium Chloride Injection USP for use with the Saline Tag Prepare the intravenous port in accordance …

In this study, we have investigated some possible production mechanisms of 82Sr by regarding 82Sr/82Rb generator. 85,87Rb(p,xn)82Sr and 80,82,83,84,86Kr(3He,xn)82Sr reaction channels have been ...

(rubidium Rb 82 Generator) To produce rubidium Rb 82 chloride injection for intravenous use Initial U.S. Approval: 1989 ... Rubidium Rb 82 chloride injection obtained from CardioGen-82 is intended only for intravenous administration using an appropriate infusion system. The usual adult (70 kg) single dose is 1480 MBq

Excess radiation exposure occurs when the levels of Sr 82 or Sr 85 in the rubidium Rb 82 chloride injection exceed limits. (5.2) Record eluate volume, including waste and test volumes. (2.5) Strictly adhere to the generator eluate testing protocol (2.6, 2.7) Stop using the generator if it reaches any of its Expiration Limits (2.8)

Rubidium Chloride Rb-82 injection is formed. The resulting material is radioactive. Rubidium Rb-82 (eluent from CardioGen-82 generator) decays by positron emission and associated gamma emission with a physical half-life of 75 seconds. The specific gamma ray constant for Rb-82 is 6.1 R /h-mCi at 1 cm. The first half-value layer is 0.7 cm of lead ...

RUBY-FILL® (Rubidium Rb 82 Generator) and Elution System; Canada; Colombia; Registered Office; Jubilant DraxImage Inc. dba Jubilant Radiopharma 16751 TransCanada Highway Kirkland, Montréal, Québec, H9H 4J4, Canada; Tel.: +1 800 361 2356; Registered Office; Jubilant Pharma Holdings Inc.

DRAXIMAGE® Sestamibi. Smart-Fill system. RUBY-FILL® (Rubidium Rb 82 Generator) and Elution System. Canada. Colombia.

Excess radiation exposure occurs when the levels of Sr 82 or Sr 85 in the rubidium Rb 82 chloride injection exceed limits. Record eluate volume, including waste and test volumes. Strictly adhere to the generator eluate testing protocol. Stop using the generator if it reaches any of its Expiration Limits .

Rubidium-82 (Rb-82) and nitrogen-13 (N-13) ammonia are clinically used PET perfusion tracers, whereas oxygen-15 (O-15) water is a research perfusion tracer. Rb-82 is the most commonly used PET perfusion tracer, with a half-life of 76 seconds, and is produced by a strontium-83 generator. The strontium generator has a half-life of 23 days and is ...

The Rubidium Elution System has been exclusively designed to be used with the RUBY-FILL® generator and to deliver accurate doses of Rb-82 Chloride to patients. Indication. …

1045 Introduction: PET myocardial perfusion imaging (MPI) with rubidium-82 (Rb-82) is being more widely adopted due to superior diagnostic accuracy and availability without the need for an onsite cyclotron. Rb-82 is obtained by eluting a Sr-82/Rb-82 generator via an automated system, creating 82RbCl for direct patient injection. …

Rubidium-82 chloride (Rb-82) (T 1/2 = 75 sec) is a chemical analog of Tl-201 chloride used for the assessment of coronary artery disease with PET. 19, 33 Rb-82 is produced as the daughter radionuclide of strontium-82 (Sr-82) eluted from a portable on-site generator renewed approximately monthly due to the physical half-life of Sr-82 (T 1/2 = 25 ...

(Sr)-82/rubidium (Rb)-82 generator elution events that resulted in patients receiving greater activities of Sr-82 and Sr-85 than those permitted under the concentration criteria in Title 10 of the Code of Federal Regulations (10 CFR) 35.204, "Permissible molybdenum-99, strontium-82, and strontium-85 concentrations."

full prescribing information for CARDIOGEN-82. CARDIOGEN-82 (rubidium Rb 82 generator) To produce rubidium Rb 82 chloride injection, for intravenous use Initial U.S. Approval: 1989 WARNING: HIGH LEVEL RADIATION EXPOSURE WITH USE OF INCORRECT ELUENT AND FAILURE TO FOLLOW THE ELUATE TESTING PROTOCOL

The RUBY-FILL® Rubidium Rb 82 Generator contains accelerator produced Strontium-82, which decays to Rubidium-82. When the generator is eluted with saline it produces a sterile, non-pyrogenic solution of Rb-82 Chloride used for Cardiac Positron Emission Tomography (PET), a non-invasive imaging procedure of the myocardium, to evaluate …

Rubidium Rb 82 injection is used in adults to help diagnose heart disease. It is used in a procedure called a positron emission tomography (PET) scan to help your …

The chemical form of Rb 82 is 82 RbCl. The amount (mCi) of Rb 82 obtained in each elution will depend on the potency of the generator. When used with the RUBY Rubidium Elution System, the generator provides ± 10% accuracy for rubidium Rb 82 chloride doses between 370-2220 MBq (10-60 mCi). When eluted at a rate of 15 -30 …

CARDIOGEN-82 ® (Rubidium Rb 82 Generator) is a closed system used to produce rubidium Rb 82 chloride injection for intravenous administration. Rubidium Rb 82 chloride injection is a radioactive …

specifically with the RUBY-FILL Rubidium Rb 82 Generator) for eluate testing. Perform Mandatory Eluate Testing (i.e. Quality Control test) to determine Rb 82, Sr 82, and Sr 85 levels: 1. Daily - Before administering rubidium Rb 82 chloride injection to the first patient each day. 2. Repeat Every 4 patientsafter an Alert Limit has been detected.

The chemical form of Rb 82 is 82 RbCl. The amount (mCi) of Rb 82 obtained in each elution will depend on the potency of the generator. When used with the RUBY Rubidium Elution System, the generator provides ± 10% accuracy for rubidium Rb 82 chloride doses between 370 to 2220 MBq (10 to 60 mCi).

Follow instructions in the CardioGen-82 Infusion System Model 510 or Model 1700 Operator's Manual for the set up and intravenous infusion of rubidium Rb 82 chloride injection dose (s). 1,2. The generator, when used with either infusion system, provides ± 10% accuracy for rubidium Rb 82 chloride injection between doses of 1,110 …